3R Benefits of Using Star-Oddi Micro-HRT for Monitoring Temperature and Heart Rate in Group Housed Laboratory Mice
使用Star-Oddi micro-HRT监测
群养实验室小鼠体温与心率的3个优势
Problem
The laboratory mouse is the most common animal model used in scientific research. It has genetic similarities to humans, they can be easily genetically modified, they have short life cycles and fast reproduction. They are cost-effective and manageable with well-established regulatory and ethical framework.
Longitudinally collecting, quantifying, and analyzing cardiovascular (heart rate) and metabolic (temperature) data in group-housed, freely moving, awake experimental mice has been historically challenging. Current technologies (ie., some telemetry) remain very limited in capability due to size constrain not present in larger animals such as NHP and rats and are also often cost-prohibitive.
This study explores the benefits, data quality and practicality of implanting Star-Oddi DST micro-HRT data loggers that were originally designed for laboratory rats into laboratory mice to monitor body temperature and ECG derived heart rate (HR).
问题
实验室小鼠是科学研究中最常用的动物模型。它与人类有遗传相似性，可以很容易地进行基因改造，生命周期短，繁殖快。它们具有成本效益，并且可以通过完善的监管和道德框架进行管理。
在群居、自由移动、清醒的实验小鼠中纵向收集、量化和分析心血管（心率）和代谢（温度）数据在历史上一直具有挑战性。由于NHP和大鼠等大型动物没有尺寸限制，目前的技术（即一些遥测技术）在能力上仍然非常有限，而且成本也往往过高。
本研究探讨了将最初为实验室大鼠设计的Star Oddi DST Micro-HRT数据记录器植入实验室小鼠体内以监测体温和心电图心率（HR）的益处、数据质量和实用性。
