The effect of divergent selection on the basal metabolic rate on body temperature in males of laboratory mice with different levels of obesity
不同肥胖程度实验室雄性小鼠基础代谢率对体温的影响
Abstract
Objectives
Basal metabolic rate (BMR) and body temperature are evolutionarily coupled in mammals. Low values of both BMR and body temperature, and high lability (instability) of body temperature in response to unfavorable conditions are important predictors of obesity risk. Therefore, clarifying their mutual dependencies is important for interpreting the results of translational studies. The aim of our study was to determine how large intraspecific variation in BMR affects body temperature and its lability in laboratory rodents with different levels of obesity.
Methods
We measured core body temperature by means of implanted loggers in males from two lines of laboratory mice divergently selected for high (H-BMR) or low (L-BMR) BMR and acclimated to 23 °C and 4 °C.
摘要：
目标
基础代谢率（BMR）与体温在哺乳动物中具有进化上的关联性。BMR和体温的低值，以及体温在不利条件下表现出的高波动性（不稳定性），都是肥胖风险的重要预测指标。因此，明确二者间的相互依赖关系对于解读转化研究结果至关重要。本研究旨在探讨BMR的物种内变异如何影响不同肥胖程度实验啮齿动物的体温及其波动性。
方法
我们通过植入记录仪测量了来自两个实验室小鼠品系的雄性小鼠的核心体温，这两个品系分别选择了高（H-BMR）或低（L-BMR）BMR，并适应了23℃ °C和4 °C.
